Neer dose movie in usa new york5/27/2023 ![]() The structural mechanism of cholesterol modulation of GIRK channels is not well understood. ![]() In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative diseases such as Alzheimer’s dementia and Parkinson’s disease. G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability.
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